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|Title:||A Peptide Antagonist of the TLR4-MD2 Interaction|
|Citation:||ChemBioChem, 2009; 10(4):645-649|
|Publisher:||Wiley-VCH Verlag GMBH|
|Peter F. Slivka, Mitesh Shridhar, Gui-in Lee, Deanne W. Sammond, Mark R. Hutchinson, Alexander J. Martinko, Madison M. Buchanan, Page W. Sholar, Jeffrey J. Kearney, Jacqueline A. Harrison, Linda R. Watkins and Hang Yin|
|Abstract:||Toll-like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently, toll-like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS-related diseases such as sepsis and chronic pain. We herein report a chemical biology approach by using a rationally designed peptide inhibitor to disrupt the TLR4-MD2 association, thereby blocking TLR4 signaling.|
|Keywords:||Cell Line; Animals; Mice; Peptides; Adaptor Proteins, Signal Transducing; Computational Biology; Protein Conformation; Protein Binding; Models, Molecular; Toll-Like Receptor 4; Lymphocyte Antigen 96|
|Appears in Collections:||Pharmacology publications|
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