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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/57096
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dc.contributor.authorSlivka, P.-
dc.contributor.authorShridhar, M.-
dc.contributor.authorLee, G.-
dc.contributor.authorSammond, D.-
dc.contributor.authorHutchinson, M.-
dc.contributor.authorMartinko, A.-
dc.contributor.authorBuchanan, M.-
dc.contributor.authorSholar, P.-
dc.contributor.authorKearney, J.-
dc.contributor.authorHarrison, J.-
dc.contributor.authorWatkins, L.-
dc.contributor.authorYin, H.-
dc.date.issued2009-
dc.identifier.citationChemBioChem: a European journal of chemical biology, 2009; 10(4):645-649-
dc.identifier.issn1439-4227-
dc.identifier.issn1439-7633-
dc.identifier.urihttp://hdl.handle.net/2440/57096-
dc.description.abstractToll-like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently, toll-like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS-related diseases such as sepsis and chronic pain. We herein report a chemical biology approach by using a rationally designed peptide inhibitor to disrupt the TLR4-MD2 association, thereby blocking TLR4 signaling.-
dc.description.statementofresponsibilityPeter F. Slivka, Mitesh Shridhar, Gui-in Lee, Deanne W. Sammond, Mark R. Hutchinson, Alexander J. Martinko, Madison M. Buchanan, Page W. Sholar, Jeffrey J. Kearney, Jacqueline A. Harrison, Linda R. Watkins and Hang Yin-
dc.language.isoen-
dc.publisherWiley-VCH Verlag GMBH-
dc.source.urihttp://dx.doi.org/10.1002/cbic.200800769-
dc.subjectCell Line-
dc.subjectAnimals-
dc.subjectMice-
dc.subjectPeptides-
dc.subjectAdaptor Proteins, Signal Transducing-
dc.subjectComputational Biology-
dc.subjectProtein Conformation-
dc.subjectProtein Binding-
dc.subjectModels, Molecular-
dc.subjectToll-Like Receptor 4-
dc.subjectLymphocyte Antigen 96-
dc.titleA Peptide Antagonist of the TLR4-MD2 Interaction-
dc.typeJournal article-
dc.identifier.doi10.1002/cbic.200800769-
pubs.publication-statusPublished-
dc.identifier.orcidHutchinson, M. [0000-0003-2154-5950]-
Appears in Collections:Aurora harvest 5
Pharmacology publications

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