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|Title:||Consistent and reproducible slice selection in rodent brain using a novel stereotaxic device for MRI|
|Citation:||Journal of Neuroscience Methods, 2004; 136(1):99-102|
|Publisher:||Elsevier Science BV|
|S. T. Fricke, R. Vink, C. Chiodo, I. Cernak, L. Ileva and A. I. Faden|
|Abstract:||Typically small animal radiological images are obtained after placing the animal in the center of the imaging device using beds or platforms, and then adjusting the position after obtaining a scout image. Such a process does not permit the reproducible visualization of the same anatomical plane with repeated examinations. We have developed a device that allows stereotaxic placement of an animal in precisely the same position for repeated examinations. The instrument incorporates a full range of physiological monitoring and life support systems including temperature control, anesthesia delivery and respiratory monitoring. Using magnetic resonance imaging (MRI), the accuracy and reliability of this device is demonstrated in a rat traumatic brain injury (TBI) model.|
|Keywords:||stereotaxic; rat; mouse; magnetic resonance spectroscopy; CT; neurotrauma; stroke; PET|
|Description:||Available online 18 March 2004.|
|Rights:||Copyright © 2004 Elsevier B.V. All rights reserved.|
|Appears in Collections:||Pathology publications|
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