Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/57170
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Type: Journal article
Title: The preterm piglet - a model in the study of oesophageal development in preterm neonates
Author: Rasch, S.
Sangild, P.
Gregersen, H.
Schmidt, M.
Omari, T.
Lau, C.
Citation: Acta Paediatrica, 2010; 99(2):201-208
Publisher: Taylor & Francis As
Issue Date: 2010
ISSN: 0803-5253
1651-2227
Statement of
Responsibility: 
S Rasch, PT Sangild, H Gregersen, M Schmidt, T Omari and C Lau
Abstract: Aim: Preterm infants have difficulty in attaining independent oral feeding. This can ensue from inadequate sucking, swallowing and/or respiration. In impeding bolus transport, immature oesophageal motility may also be a cause. As studies on the development of oesophageal motility are invasive in preterm infants, the preterm piglet was investigated as a potential research model. Methods: Oesophageal motility (EM) of term (n = 6) and preterm (n = 15) piglets were monitored by manometry for 10 min immediately following bottle feeding on days 1-2 and 3-4 of life. Results: Piglets' oral feeding performance and EM were similar to those of their human counterparts. Term piglets readily completed their feeding, whereas their preterm counterparts did not. They also presented with greater peristaltic activity and propagating velocity. Peristaltic activity remained unchanged over time in preterm piglets, but an increase in synchronous and decrease in incomplete motor activity were noted. Preterm piglets that developed symptoms analogous to necrotizing enterocolitis (NEC) demonstrated uncharacteristic oesophageal activity. Conclusion: Immature EM may cause oral feeding difficulties. NEC-like symptoms may adversely affect EM. The piglet is a valid research model for studying human infant oral feeding and oesophageal development.
Keywords: Oesophageal motility; Oral feeding; Prematurity
Rights: © 2009 The Author(s)/Journal Compilation © 2009 Foundation Acta Pædiatrica
RMID: 0020100094
DOI: 10.1111/j.1651-2227.2009.01564.x
Appears in Collections:Paediatrics publications

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