Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/57253
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Liver failure after major hepatic resection
Author: Garcea, G.
Maddern, G.
Citation: Journal of Hepato-Biliary-Pancreatic Surgery, 2009; 16(2):145-155
Publisher: Springer Tokyo
Issue Date: 2009
ISSN: 0944-1166
1436-0691
Statement of
Responsibility: 
Giuseppe Garcea and G. J. Maddern
Abstract: Introduction: The consequence of excessive liver resection is the inexorable development of progressive liver failure characterised by the typical stigmata associated with this condition, including worsening coagulopathy, hyperbilirubinaemia and encephalopathy. The focus of this review will be to investigate factors contributing to hepatocyte loss and impaired regeneration. Methods: A literature search was undertaken of Pubmed and related search engines, examining for articles relating to hepatic failure following major hepatectomy. Results: In spite of improvements in adjuvant chemotherapy and increasing surgical confidence and expertise, the parameters determining how much liver can be resected have remained largely unchanged. A number of preoperative, intraoperative and post-operative factors all contribute to the likelihood of liver failure after surgery. Conclusions: Given the magnitude of the surgery, mortality and morbidity rates are extremely good. Careful patient selection and preservation of an obligate volume of remnant liver is essential. Modifiable causes of hepatic failure include avoidance of sepsis, drainage of cholestasis with restoration of enteric bile salts and judicious use of portal triad inflow occlusion intra-operatively. Avoidance of postoperative sepsis is most likely to be achieved by patient selection, meticulous intra-operative technique and postoperative care. Modulation of portal vein pressures postoperatively may further help reduce the risk of liver failure.
Keywords: Liver failure
Liver resection
DOI: 10.1007/s00534-008-0017-y
Appears in Collections:Aurora harvest
Surgery publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.