Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/57272
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dc.contributor.authorBovine Genome Sequencing and Analysis Consortiumen
dc.contributor.authorElsik, C.en
dc.contributor.authorTellam, R.en
dc.contributor.authorWorley, K.en
dc.contributor.otherAdelson, David Louisen
dc.date.issued2009en
dc.identifier.citationScience, 2009; 324(5926):522-528en
dc.identifier.issn0036-8075en
dc.identifier.issn1095-9203en
dc.identifier.urihttp://hdl.handle.net/2440/57272-
dc.descriptionDavid L. Adelson is a member of The Bovine Genome Sequencing and Analysis Consortium.en
dc.description.abstractTo understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.en
dc.description.statementofresponsibilityThe Bovine Genome Sequencing and Analysis Consortium, Christine G. Elsik, Ross L. Tellam, Kim C. Worleyen
dc.language.isoenen
dc.publisherAmerican Association for the Advancement of Scienceen
dc.rightsCopyright 2009 by the American Association for the Advancement of Science; all rights reserved.en
dc.subjectBovine Genome Sequencing and Analysis Consortium; Animals; Animals, Domestic; Cattle; Humans; Proteins; MicroRNAs; Sequence Analysis, DNA; Evolution, Molecular; Species Specificity; Alternative Splicing; Synteny; Genome; Molecular Sequence Data; Female; Male; Genetic Variation; Biological Evolutionen
dc.titleThe genome sequence of Taurine cattle: a window to ruminant biology and evolutionen
dc.typeJournal articleen
dc.identifier.rmid0020095513en
dc.identifier.doi10.1126/science.1169588en
dc.identifier.pubid35692-
pubs.library.collectionMolecular and Biomedical Science publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Molecular and Biomedical Science publications
Environment Institute publications

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