Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Paclitaxel exposure and its effective decontamination|
|Citation:||Journal of Pharmacy Practice and Research, 2009; 39(3):181-185|
|Publisher:||Society of Hospital Pharmacists of Australia|
|Su-Gil Lee, Fotios Ambados, Michael Tkaczuk, and Ganyk Jankewicz|
|Abstract:||Background: Apart from generic guidelines for the safe handling of cytotoxic drugs in pharmacy departments, there is no specific published literature pertaining to cleaning procedures and inadvertent exposure to paclitaxel. Aim: To examine occupational exposure to paclitaxel; to identify an effective decontamination reagent; and to determine suitable glove type for skin protection. Method: 8 decontamination reagents were tested for paclitaxel degradation. Air sampling filters, Ghost Wipes and cotton wipes were tested under different storage conditions (room temperature, ≤4°C) for 3 days. Disposable latex and nitrile gloves were tested for paclitaxel permeation using a one-inch ASTM standard test cell. Environmental (airborne and surface) monitoring was carried out in the cytotoxic compounding and work areas. High performance liquid chromatography and photo-ionisation detector were used for sample analysis and glove permeation tests, respectively. Results: Isopropanol 50% and ethanol 60% demonstrated the least degradation (< 2%) of paclitaxel in 80 minutes. Sodium hypochlorite 0.5% w/v showed the greatest degradation (> 99%) of paclitaxel in 20 minutes. Sample wipes should be stored at ≤4°C until analysis. Paclitaxel and sodium hypochlorite 0.5% w/v did not permeate through the latex and nitrile gloves after 4 hours of continuous exposure. No paclitaxel was detected in airborne and surface wipe samples. Conclusion: No detectable paclitaxel was measured within the cytotoxic compounding area. Sodium hypochlorite 0.5% w/v is a suitable decontamination reagent for paclitaxel surface contamination. Wearing either latex or nitrile gloves can prevent contamination when handling paclitaxel.|
|Appears in Collections:||Aurora harvest 5|
Public Health publications
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.