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Type: Journal article
Title: Modulation of lymphocyte migration to the murine spleen after marginal zone macrophage phagocytosis of blood-borne particulate material
Author: Lyons, A.
Watkins, M.
Simpson, C.
Muller, H.
Citation: Immunological Investigations: a journal of molecular and cellular immunology, 2006; 35(1):75-92
Publisher: Marcel Dekker
Issue Date: 2006
ISSN: 0882-0139
Statement of
A. Bruce Lyons, Marcus Watkins, Campbell C. Simpson, and H. Konrad Muller
Abstract: Our previous studies identified a role for MZM in the movement of lymphocytes into the splenic white pulp. Here we show that phagocytosis of colloidal carbon by marginal zone macrophages results in a splenic influx of B lymphocytes, and T lymphocytes of memory/activated phenotype, with concomitant upregulation of B Lymphocye Chemoattractant (BLC, CXCL13) mRNA, a chemokine acting on B and memory/activated T lymphocytes. The recruitment of B cells and activated T cells to the spleen after phagocytic uptake would allow an immune response against blood-borne pathogens to be quickly and effectively mounted by bringing together the two key cell types responsible for generating humoral immunity.
Keywords: CXCL13
B lymphocyte
Rights: Copyright © Taylor & Francis Group, LLC
DOI: 10.1080/08820130500496845
Appears in Collections:Aurora harvest
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