Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/57610
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Type: Journal article
Title: Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease
Author: Rolan, P.
Hutchinson, M.
Johnson, K.
Citation: Expert Opinion on Pharmacotherapy, 2009; 10(17):2897-2904
Publisher: Ashley Publications Ltd.
Issue Date: 2009
ISSN: 1465-6566
1744-7666
Statement of
Responsibility: 
P. Rolan, M.R. Hutchinson & K.W. Johnson
Abstract: Ibudilast is a relatively nonselective phosphodiesterase inhibitor which has been marketed for almost 20 years in Japan for treating asthma. More recently it has been found to have anti-inflammatory activity in both the peripheral immune system and in the CNS via glial cell attenuation. This CNS-directed anti-inflammatory activity is of potential use in the treatment of multiple sclerosis, neuropathic pain, and in the improved efficacy and safety of opioids by decreasing opioid tolerance, withdrawal and reinforcement. Its suitable pharmacokinetics and generally good tolerability make it a promising potential treatment for these conditions.
Keywords: glia; ibudilast; multiple sclerosis; neuropathic pain; priming
Description: © 2009 Informa UK Ltd
RMID: 0020094448
DOI: 10.1517/14656560903426189
Appears in Collections:Pharmacology publications

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