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dc.contributor.authorRolan, P.en
dc.contributor.authorHutchinson, M.en
dc.contributor.authorJohnson, K.en
dc.identifier.citationExpert Opinion on Pharmacotherapy, 2009; 10(17):2897-2904en
dc.description© 2009 Informa UK Ltden
dc.description.abstractIbudilast is a relatively nonselective phosphodiesterase inhibitor which has been marketed for almost 20 years in Japan for treating asthma. More recently it has been found to have anti-inflammatory activity in both the peripheral immune system and in the CNS via glial cell attenuation. This CNS-directed anti-inflammatory activity is of potential use in the treatment of multiple sclerosis, neuropathic pain, and in the improved efficacy and safety of opioids by decreasing opioid tolerance, withdrawal and reinforcement. Its suitable pharmacokinetics and generally good tolerability make it a promising potential treatment for these conditions.en
dc.description.statementofresponsibilityP. Rolan, M.R. Hutchinson & K.W. Johnsonen
dc.publisherAshley Publications Ltd.en
dc.subjectglia; ibudilast; multiple sclerosis; neuropathic pain; primingen
dc.titleIbudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological diseaseen
dc.typeJournal articleen
pubs.library.collectionPharmacology publicationsen
Appears in Collections:Pharmacology publications

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