Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/57744
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Type: Journal article
Title: Minimal gene regulatory circuits that can count like bacteriophage lambda
Author: Avlund, M.
Dodd, I.
Sneppen, K.
Krishna, S.
Citation: Journal of Molecular Biology, 2009; 394(4):681-693
Publisher: Academic Press Ltd Elsevier Science Ltd
Issue Date: 2009
ISSN: 0022-2836
1089-8638
Statement of
Responsibility: 
M. Avlund, Ian B. Dodd, K. Sneppen and S. Krishna
Abstract: The behavior of living systems is dependent on large dynamical gene regulatory networks (GRNs). However, the functioning of even the smallest GRNs is difficult to predict. The bistable GRN of bacteriophage lambda is able to count to make a decision between lysis and lysogeny on the basis of the number of phages infecting the cell, even though replication of the phage genome eliminates this initial difference. By simulating the behavior of a large number of random transcriptional GRNs, we show that a surprising variety of GRNs can carry out this complex task, including simple CI–Cro-like mutual repression networks. Thus, our study extends the repertoire of simple GRNs. Counterintuitively, the major effect of the addition of CII-like regulation, generally thought to be needed for counting by lambda, was to improve the ability of the networks to complete a simulated prophage induction. Our study suggests that additional regulatory mechanisms to decouple Cro and CII levels may exist in lambda and that infection counting could be widespread among temperate bacteriophages, many of which contain CI–Cro-like circuits.
Keywords: epigenetics; feedback; network motif; switches; developmental decisions
RMID: 0020093643
DOI: 10.1016/j.jmb.2009.09.053
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/622890/description#description
Appears in Collections:Molecular and Biomedical Science publications

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