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dc.contributor.authorAvlund, M.en
dc.contributor.authorDodd, I.en
dc.contributor.authorSneppen, K.en
dc.contributor.authorKrishna, S.en
dc.identifier.citationJournal of Molecular Biology, 2009; 394(4):681-693en
dc.description.abstractThe behavior of living systems is dependent on large dynamical gene regulatory networks (GRNs). However, the functioning of even the smallest GRNs is difficult to predict. The bistable GRN of bacteriophage lambda is able to count to make a decision between lysis and lysogeny on the basis of the number of phages infecting the cell, even though replication of the phage genome eliminates this initial difference. By simulating the behavior of a large number of random transcriptional GRNs, we show that a surprising variety of GRNs can carry out this complex task, including simple CI–Cro-like mutual repression networks. Thus, our study extends the repertoire of simple GRNs. Counterintuitively, the major effect of the addition of CII-like regulation, generally thought to be needed for counting by lambda, was to improve the ability of the networks to complete a simulated prophage induction. Our study suggests that additional regulatory mechanisms to decouple Cro and CII levels may exist in lambda and that infection counting could be widespread among temperate bacteriophages, many of which contain CI–Cro-like circuits.en
dc.description.statementofresponsibilityM. Avlund, Ian B. Dodd, K. Sneppen and S. Krishnaen
dc.publisherAcademic Press Ltd Elsevier Science Ltden
dc.subjectepigenetics; feedback; network motif; switches; developmental decisionsen
dc.titleMinimal gene regulatory circuits that can count like bacteriophage lambdaen
dc.typeJournal articleen
pubs.library.collectionMolecular and Biomedical Science publicationsen
Appears in Collections:Molecular and Biomedical Science publications

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