Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/57780
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Type: Journal article
Title: Population-based surveillance for scedosporiosis in Australia: epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection
Author: Heath, C.
Slavin, M.
Sorrell, T.
Handke, R.
Harun, A.
Phillips, M.
Nguyen, Q.
Delhaes, L.
Ellis, D.
Meyer, W.
Chen, S.
Citation: Clinical Microbiology and Infection, 2009; 15(7):689-693
Publisher: Blackwell Science Ltd
Issue Date: 2009
ISSN: 1198-743X
1469-0691
Statement of
Responsibility: 
C. H. Heath, M. A. Slavin, T. C. Sorrell, R. Handke, A. Harun, M. Phillips, Q. Nguyen, L. Delhaes, D. Ellis, W. Meyer and S. C. A. Chen, on behalf of the Australian Scedosporium Study Group
Abstract: Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S. aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum.
Keywords: Epidemiology; Scedosporium; Scedosporium aurantiacum
Description: Article first published online: 22 JUN 2009
Rights: Journal compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases
RMID: 0020096054
DOI: 10.1111/j.1469-0691.2009.02802.x
Appears in Collections:Molecular and Biomedical Science publications

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