Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Population-based surveillance for scedosporiosis in Australia: epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection|
|Citation:||Clinical Microbiology and Infection, 2009; 15(7):689-693|
|Publisher:||Blackwell Science Ltd|
|C. H. Heath, M. A. Slavin, T. C. Sorrell, R. Handke, A. Harun, M. Phillips, Q. Nguyen, L. Delhaes, D. Ellis, W. Meyer and S. C. A. Chen, on behalf of the Australian Scedosporium Study Group|
|Abstract:||Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S. aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum.|
|Keywords:||Epidemiology; Scedosporium; Scedosporium aurantiacum|
|Description:||Article first published online: 22 JUN 2009|
|Rights:||Journal compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases|
|Appears in Collections:||Molecular and Biomedical Science publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.