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Type: Journal article
Title: Population-based surveillance for scedosporiosis in Australia: epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection
Author: Heath, C.
Slavin, M.
Sorrell, T.
Handke, R.
Harun, A.
Phillips, M.
Nguyen, Q.
Delhaes, L.
Ellis, D.
Meyer, W.
Chen, S.
Citation: Clinical Microbiology and Infection, 2009; 15(7):689-693
Publisher: Blackwell Science Ltd
Issue Date: 2009
ISSN: 1198-743X
Statement of
C. H. Heath, M. A. Slavin, T. C. Sorrell, R. Handke, A. Harun, M. Phillips, Q. Nguyen, L. Delhaes, D. Ellis, W. Meyer and S. C. A. Chen, on behalf of the Australian Scedosporium Study Group
Abstract: Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S. aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum.
Keywords: Epidemiology
Scedosporium aurantiacum
Description: Article first published online: 22 JUN 2009
Rights: Journal compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases
DOI: 10.1111/j.1469-0691.2009.02802.x
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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