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Type: Journal article
Title: Probiotics and their derivatives as treatments for inflammatory bowel disease
Author: Prisciandaro, L.
Geier, M.
Butler, R.
Cummins, A.
Howarth, G.
Citation: Inflammatory Bowel Diseases, 2009; 15(12):1906-1914
Publisher: Lippincott Williams & Wilkins
Issue Date: 2009
ISSN: 1078-0998
Statement of
Luca Prisciandaro, Mark Geier, Ross Butler, Adrian Cummins and Gordon Howarth
Abstract: Inflammatory bowel disease (IBD) is a chronic relapsing disorder that is increasing in prevalence in Western society and has been linked to the development of colorectal cancer. There remains no definitive treatment for IBD, hence recent investigations have focused on the development of new therapeutics, including probiotics, which can reduce intestinal inflammation and restore balance to the gastrointestinal microbiota. Probiotics are currently being studied in greater detail, albeit predominantly in animal models of IBD. Clinical studies have yielded promising findings and justify further investigation. Furthermore, the use of inactivated probiotics as well as the soluble products produced by these bacteria has demonstrated therapeutic potential, and may in fact be more suitable, as there is no risk of sepsis associated with their administration and they can be manufactured with greater quality control. Further research is essential to define the mechanism and source of probiotic action, and to identify more efficacious strains, while future clinical trials must focus on determining whether the bacterial and genetic profiles of IBD patients influence the effectiveness of treatment
Keywords: inactivated bacteria; inflammatory bowel disease; probiotics; supernatants
RMID: 0020094282
DOI: 10.1002/ibd.20938
Appears in Collections:Agriculture, Food and Wine publications

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