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Type: Journal article
Title: Characterisation of ATRX, DMRT1, DMRT7 and WT1 in the platypus (Ornithorhynchus anatinus)
Author: Tsend-Ayush, E.
Lim, S.
Pask, A.
Mohd Hamdan, D.
Renfree, M.
Grutzner, F.
Citation: Reproduction Fertility and Development, 2009; 21(8):985-991
Publisher: C S I R O Publishing
Issue Date: 2009
ISSN: 1031-3613
Statement of
Enkhjargal Tsend-Ayush, Shu Ly Lim, Andrew J. Pask, Diana Demiyah Mohd Hamdan, Marilyn B. Renfree and Frank Grützner
Abstract: One of the most puzzling aspects of monotreme reproductive biology is how they determine sex in the absence of the SRY gene that triggers testis development in most other mammals. Although monotremes share a XX female/XY male sex chromosome system with other mammals, their sex chromosomes show homology to the chicken Z chromosome, including the DMRT1 gene, which is a dosage-dependent sex determination gene in birds. In addition, monotremes feature an extraordinary multiple sex chromosome system. However, no sex determination gene has been identified as yet on any of the five X or fiveY chromosomes and there is very little knowledge about the conservation and function of other known genes in the monotreme sex determination and differentiation pathway. We have analysed the expression pattern of four evolutionarily conserved genes that are important at different stages of sexual development in therian mammals. DMRT1 is a conserved sex-determination gene that is upregulated in the male developing gonad in vertebrates, while DMRT7 is a mammal-specific spermatogenesis gene. ATRX, a chromatin remodelling protein, lies on the therian X but there is a testis-expressedY-copy in marsupials. However, in monotremes, the ATRX orthologue is autosomal. WT1 is an evolutionarily conserved gene essential for early gonadal formation in both sexes and later in testis development.We show that these four genes in the adult platypus have the same expression pattern as in other mammals, suggesting that they have a conserved role in sexual development independent of genomic location.
Keywords: Ovary; sex chromosomes; sex determination; sexual differentiation; testis
Rights: © CSIRO 2009
RMID: 0020093149
DOI: 10.1071/RD09090
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Appears in Collections:Molecular and Biomedical Science publications
Environment Institute Leaders publications

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