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https://hdl.handle.net/2440/57960
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dc.contributor.author | Stadler, D. | - |
dc.contributor.author | McEvoy, R. | - |
dc.contributor.author | Sprecher, K. | - |
dc.contributor.author | Thomson, K. | - |
dc.contributor.author | Ryan, M. | - |
dc.contributor.author | Thompson, C. | - |
dc.contributor.author | Catcheside, P. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Sleep, 2009; 32(12):1579-1587 | - |
dc.identifier.issn | 0161-8105 | - |
dc.identifier.issn | 1550-9109 | - |
dc.identifier.uri | http://hdl.handle.net/2440/57960 | - |
dc.description.abstract | <h4>Study objectives</h4>Abdominal obesity, particularly common in centrally obese males, may have a negative impact on upper airway (UA) function during sleep. For example, cranial displacement of the diaphragm with raised intra-abdominal pressure may reduce axial tension exerted on the UA by intrathoracic structures and increase UA collapsibility during sleep.<h4>Design</h4>This study aimed to examine the effect of abdominal compression on UA function during sleep in obese male obstructive sleep apnea patients.<h4>Setting</h4>Participants slept in a sound-insulated room with physiologic measurements controlled from an adjacent room.<h4>Participants</h4>Fifteen obese (body mass index: 34.5 +/- 1.1 kg/m2) male obstructive sleep apnea patients (apnea-hypopnea index: 58.1 +/- 6.8 events/h) aged 50 +/- 2.6 years participated.<h4>Interventions</h4>Gastric (PGA) and transdiaphragmatic pressures (P(DI)), UA closing pressure (UACP), UA airflow resistance (R(UA)), and changes in end-expiratory lung volume (EELV) were determined during stable stage 2 sleep with and without abdominal compression, achieved via inflation of a pneumatic cuff placed around the abdomen. UACP was assessed during brief mask occlusions.<h4>Measurements and results</h4>Abdominal compression significantly decreased EELV by 0.53 +/- 0.24 L (P=0.045) and increased PGA (16.2 +/- 0.8 versus 10.8 +/- 0.7 cm H2O, P < 0.001), P(DI) (11.7 +/- 0.9 versus 7.6 +/- 1.2 cm H2O, P < 0.001) and UACP (1.4 +/- 0.8 versus 0.9 +/- 0.9 cm H2O, P = 0.039) but not R(UA)(6.5 +/- 1.4 versus 6.9 +/- 1.4 cm H2O x L/s, P=0.585).<h4>Conclusions</h4>Abdominal compression negatively impacts on UA collapsibility during sleep and this effect may help explain strong associations between central obesity and obstructive sleep apnea. | - |
dc.description.statementofresponsibility | Daniel L. Stadler, R. Doug McEvoy, Kate E. Sprecher, Kieron J. Thomson, Melissa K. Ryan, Courtney C. Thompson, Peter G. Catcheside | - |
dc.description.uri | http://www.ncbi.nlm.nih.gov/pubmed/20041593 | - |
dc.language.iso | en | - |
dc.publisher | Amer Academy Sleep Medicine | - |
dc.rights | Copyright © 2009 by the Associated Professional Sleep Societies, LLC | - |
dc.source.uri | http://dx.doi.org/10.1093/sleep/32.12.1579 | - |
dc.subject | Obstructive sleep apnea | - |
dc.subject | abdominal loading | - |
dc.subject | lung volume | - |
dc.subject | caudal traction | - |
dc.title | Abdominal compression increases upper airway collapsibility during sleep in obese male obstructive sleep apnea patients | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/sleep/32.12.1579 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McEvoy, R. [0000-0002-5759-0094] | - |
dc.identifier.orcid | Catcheside, P. [0000-0002-9372-6788] | - |
Appears in Collections: | Aurora harvest Physiology publications |
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