Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Finding the place of histone deacetylase inhibitors in prostate cancer therapy|
|Citation:||Expert Review of Clinical Pharmacology, 2009; 2(6):619-630|
|Publisher:||Expert Reviews Ltd.|
|Deborah L Marrocco-Tallarigo, Margaret M Centenera, Howard I Scher, Wayne D Tilley and Lisa M Butler|
|Abstract:||Histone deacetylase inhibitors (HDACIs) are showing promise as therapeutic agents for hematological malignancies and solid tumors. In the case of prostate cancer, HDACIs are effective at inhibiting proliferation and inducing apoptosis in a range of in vitro and in vivo experimental models. Recent studies have revealed that the actions of HDACIs in prostate cancer cells extend beyond regulation of histone acetylation and affect proteins involved in maintaining cellular homeostasis and tumor progression, including the androgen receptor, p21WAF1 and VEGF. The broad spectrum of HDACI targets has allowed rational design of combinations with other therapeutic agents to target multiple pathways involved in prostate cancer progression, including angiogenesis and androgen signaling. In particular, synergistic inhibition of prostate cancer cell growth has been demonstrated using HDACIs in combination with radio- and chemo-therapy, Apo2L/TRAIL, angiogenesis inhibitors, heat-shock protein 90 inhibitors and androgen receptor antagonists. This review examines the current understanding of the actions of HDACIs in prostate cancer cells, both in a laboratory and a clinical context and discusses the potential utility of combination strategies for the treatment of prostate cancer.|
|Keywords:||androgen signaling; clinical trials; combination therapies; histone deacetylase inhibitors; prostate cancer|
|Rights:||Copyright status unknown|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.