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Type: Journal article
Title: Axonal and neuronal amyloid precursor protein immunoreactivity in the brains of guinea pigs given tunicamycin
Author: Finnie, J.
Manavis, J.
Blumbergs, P.
Kuchel, T.
Citation: Veterinary Pathology, 2000; 37(6):677-680
Publisher: Amer Coll Vet Pathologist
Issue Date: 2000
ISSN: 0300-9858
Abstract: Amyloid precursor protein (APP) immunocytochemistry was used to study axonal and neuronal changes in guinea pig brains exposed to tunicamycin. Substantial axonal injury was found in ischemic-hypoxic foci and more generally, but this injury was not readily appreciable in conventionally stained sections. Neuronal perikaryal APP expression was also widely distributed, possibly as an acute phase response to this neurotoxin.
Keywords: Brain; Neurons; Axons; Animals; Guinea Pigs; Amyloid beta-Protein Precursor; Tunicamycin; Anti-Bacterial Agents; Immunohistochemistry; Brain Chemistry
RMID: 0001000926
DOI: 10.1354/vp.37-6-677
Appears in Collections:Pathology publications

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