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|Title:||Positron emission tomography changes management and prognostic stratification in patients with oesophageal cancer: results of a multicentre prospective study|
Ho Shon, I.
|Citation:||European Journal of Nuclear Medicine and Molecular Imaging, 2009; 36(3):354-361|
|B. E. Chatterton, I. Ho Shon, A. Baldey, N. Lenzo, A. Patrikeos, B. Kelley, D. Wong, J. E. Ramshaw, A. M. Scott|
|Abstract:||Objectives: The aims of this study were (1) to determine the incremental information provided by 18F-FDG positron emission tomography (PET) in staging patients with oesophageal cancer, and (2) to determine the impact of PET staging on post-PET clinical management of oesophageal cancer, and on prognosis. Methods: In a multicentre, single-arm open study, patients with proved oesophageal cancer without definite distant metastases and regarded as suitable for potentially curative treatment were examined by PET. Clinicians were requested to supply a management plan before and another plan after being supplied with the PET scan results. Patients were followed for at least 1 year for outcome analysis. Results: A total of 129 patients (104 men, mean age 67 y) were recruited. PET detected additional sites of disease in 53 patients (41%). Significant changes in management (high or medium impact) were observed in 38% of patients, primarily as a result of identifying additional sites of disease and/or confirming previously equivocal regional and distant metastases. Progression-free survival was significantly shorter in patients found to have additional lesions on PET (p < 0.05), but was not related to SUVmax. Conclusion: These findings demonstrate the significant impact of PET on the clinical management of patients with newly diagnosed oesophageal carcinoma, and on prognostic stratification of these patients.|
|Keywords:||¹⁸F-FDG-PET; Oesophageal cancer|
|Rights:||© Springer-Verlag 2008|
|Appears in Collections:||Medicine publications|
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