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https://hdl.handle.net/2440/58880
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dc.contributor.author | Chatterton, B. | - |
dc.contributor.author | Ho Shon, I. | - |
dc.contributor.author | Baldey, A. | - |
dc.contributor.author | Lenzo, N. | - |
dc.contributor.author | Patrikeos, A. | - |
dc.contributor.author | Kelley, B. | - |
dc.contributor.author | Wong, D. | - |
dc.contributor.author | Ramshaw, J. | - |
dc.contributor.author | Scott, A. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | European Journal of Nuclear Medicine and Molecular Imaging, 2009; 36(3):354-361 | - |
dc.identifier.issn | 1619-7070 | - |
dc.identifier.issn | 1619-7089 | - |
dc.identifier.uri | http://hdl.handle.net/2440/58880 | - |
dc.description.abstract | Objectives: The aims of this study were (1) to determine the incremental information provided by 18F-FDG positron emission tomography (PET) in staging patients with oesophageal cancer, and (2) to determine the impact of PET staging on post-PET clinical management of oesophageal cancer, and on prognosis. Methods: In a multicentre, single-arm open study, patients with proved oesophageal cancer without definite distant metastases and regarded as suitable for potentially curative treatment were examined by PET. Clinicians were requested to supply a management plan before and another plan after being supplied with the PET scan results. Patients were followed for at least 1 year for outcome analysis. Results: A total of 129 patients (104 men, mean age 67 y) were recruited. PET detected additional sites of disease in 53 patients (41%). Significant changes in management (high or medium impact) were observed in 38% of patients, primarily as a result of identifying additional sites of disease and/or confirming previously equivocal regional and distant metastases. Progression-free survival was significantly shorter in patients found to have additional lesions on PET (p < 0.05), but was not related to SUVmax. Conclusion: These findings demonstrate the significant impact of PET on the clinical management of patients with newly diagnosed oesophageal carcinoma, and on prognostic stratification of these patients. | - |
dc.description.statementofresponsibility | B. E. Chatterton, I. Ho Shon, A. Baldey, N. Lenzo, A. Patrikeos, B. Kelley, D. Wong, J. E. Ramshaw, A. M. Scott | - |
dc.language.iso | en | - |
dc.publisher | Springer-Verlag | - |
dc.rights | © Springer-Verlag 2008 | - |
dc.source.uri | http://dx.doi.org/10.1007/s00259-008-0959-y | - |
dc.subject | ¹⁸F-FDG-PET | - |
dc.subject | Oesophageal cancer | - |
dc.title | Positron emission tomography changes management and prognostic stratification in patients with oesophageal cancer: results of a multicentre prospective study | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s00259-008-0959-y | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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