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Type: Journal article
Title: Antenatal phenobarbital for reducing neonatal jaundice after red cell isoimmunization
Author: Thomas, J.
Muller, P.
Wilkinson, C.
Citation: Cochrane Database of Systematic Reviews, 2007; 2(2):CD005541-
Publisher: Update Software Ltd
Issue Date: 2007
ISSN: 1469-493X
Statement of
Joseph T Thomas, Peter Muller, Christopher S Wilkinson
Abstract: Background Neonates from isoimmunized pregnancies have increased morbidity from neonatal jaundice. The increased bilirubin from haemolysis often needs phototherapy, exchange transfusion or both after birth. Various trials in pregnant women who were not isoimmunized but had other risk factors for neonatal jaundice have shown a reduction in need for phototherapy and exchange transfusion by the use of antenatal phenobarbital. A recent retrospective case-controlled study showed reduction in the need for exchange transfusion for the neonates from isoimmunized pregnancies. Objectives To assess the effects of antenatal phenobarbital in red cell isoimmunized pregnancies in reducing the incidence of phototherapy and exchange transfusion for the neonate. Search strategy We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (June 2009). Selection criteria Randomised and quasi-randomised controlled trials of pregnant women established to have red cell isoimmunization in the current pregnancy during their antenatal testing and given phenobarbital alone or in combination with other drugs before birth. Data collection and analysis All three review authors independently assessed study eligibility and quality. Main results No trials met the inclusion criteria for this review. Authors' conclusions The use of antenatal phenobarbital to reduce neonatal jaundice in red cell isoimmunized pregnant women has not been evaluated in randomised controlled trials.
Keywords: Humans
Rh Isoimmunization
Jaundice, Neonatal
Excitatory Amino Acid Antagonists
Prenatal Care
Infant, Newborn
Description: This version first published online: April 18. 2007 Last assessed as up-to-date: June 24. 2009
Rights: Copyright © 2009 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd..
DOI: 10.1002/14651858.CD005541.pub2
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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