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Type: Journal article
Title: Immunotargeting of functional nanoparticles for MRI detection of apoptotic tumor cells
Author: Thierry, B.
Al-Ejeh, F.
Brown, M.
Majewski, P.
Griesser, H.
Citation: Advanced Materials, 2009; 21(5):541-545
Publisher: Wiley
Issue Date: 2009
ISSN: 0935-9648
Statement of
Benjamin Thierry, Fares Al-Ejeh, Michael P. Brown, Peter Majewski, and Hans J. Griesser
Abstract: Hybrid MRI nanoprobes, immunotargeted to the La ribonucleoprotein, which becomes available for binding in the cytoplasm of post-apoptotic permeable cells, are designed for the improved detection of apoptotic tumor cells. The high level of specificity achieved through the use of an optimal polyethyleneglycol interlayer makes them excellent candidates for the in vivo detection of intratumoral apoptosis.
Keywords: Apoptosis; Immunotargeting; Biointerfaces; Nanoparticles; Nanotechnology
Rights: Copyright 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
RMID: 0030001154
DOI: 10.1002/adma.200800998
Appears in Collections:Medicine publications

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