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Type: Journal article
Title: Preventing pain on injection of propofol: A comparison between lignocaine pre-treatment and lignocaine added to propofol
Author: Lee, P.
Russell, W.
Citation: Anaesthesia and Intensive Care, 2004; 32(4):482-484
Publisher: Australian Soc Anaesthetists
Issue Date: 2004
ISSN: 0310-057X
Statement of
P. Lee, W. J. Russell
Abstract: A randomized double-blind study compared two methods of preventing the pain from injection of propofol, lignocaine pre-treatment followed by propofol and lignocaine added to propofol. One hundred patients received a 4 ml solution intravenously with a venous tourniquet for 1 minute, followed by propofol mixed with 2 ml of solution. Patients were divided into two treatment groups of 50 patients each: 4 ml 1% lignocaine pre-treatment followed by propofol and 2 ml saline, or 4 ml saline followed by propofol and 2 ml 2% lignocaine. Pain was assessed with a 100 mm visual analogue scale after induction and in recovery. The incidence of injection pain was 8% in the propofol mixed with lignocaine group, and 28% in the lignocaine pre-treatment group. This difference is statistically significant (P=0.017). For those patients who had pain, the mean pain score was 26.5 on induction for the propofol with lignocaine group (n=4), while the mean score was 44.4 for the pre-treatment group (n=13). The difference was not statistically significant (P=0.25). None of the propofol mixed with lignocaine group recalled pain, while 13 of the pre-treatment group did so. Lignocaine pre-treatment does not improve the immediate or the recalled comfort of patients during propofol induction when compared to lignocaine added to propofol. It is recommended that lignocaine should be added to propofol for induction rather than given before induction.
Keywords: Humans; Pain; Lidocaine; Propofol; Anesthetics, Intravenous; Anesthetics, Local; Pain Measurement; Preanesthetic Medication; Injections, Intravenous; Double-Blind Method; Middle Aged; Female; Male
Description: Publisher's copy made available with the permission of the publisher
Rights: © Australian Society of Anaesthetists
RMID: 0020040892
DOI: 10.1177/0310057x0403200432
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Appears in Collections:Anaesthesia and Intensive Care publications

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