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Type: Journal article
Title: Cerebral effects of propofol following bolus administration in sheep
Author: Ludbrook, G.
Upton, R.
Grant, C.
Gray, E.
Citation: Anaesthesia and Intensive Care, 1996; 24(1):26-31
Issue Date: 1996
ISSN: 0310-057X
Statement of
G.L. Ludbrook, R.N. Upton, C. Grant, C. Gray
Abstract: The effects of bolus administration of propofol (50 mg, 100 mg and 200 mg) on cerebral blood flow and cerebral metabolic rate for oxygen were examined in a chronically catheterized sheep preparation. Depth of anaesthesia was simultaneously measured using a withdrawal response to a noxious electrical stimulus and it was demonstrated that the 100 mg dose induced moderate sedation while the 200 mg dose induced relatively deep anaesthesia. Propofol caused transient dose-dependent decreases in cerebral blood flow, despite minimal changes in blood pressure. These were accompanied by parallel decreases in cerebral metabolic rate but no change in cerebral oxygen extraction. As cerebrovascular responses in the sheep appear similar to those in man, the parallel changes in cerebral blood flow and metabolic rate demonstrated in this study supports the suitability of propofol as a neuroanaesthetic agent.
Keywords: Brain
Anesthetics, Intravenous
Anesthesia, Intravenous
Random Allocation
Blood Pressure
Cerebrovascular Circulation
Dose-Response Relationship, Drug
Description: Publisher's copy made available with the permission of the publisher © 1996 Australian Society of Anaesthetists
DOI: 10.1177/0310057x9602400105
Published version:
Appears in Collections:Anaesthesia and Intensive Care publications
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