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https://hdl.handle.net/2440/5920
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Type: | Journal article |
Title: | Cerebral effects of propofol following bolus administration in sheep |
Author: | Ludbrook, G. Upton, R. Grant, C. Gray, E. |
Citation: | Anaesthesia and Intensive Care, 1996; 24(1):26-31 |
Publisher: | AUSTRALIAN SOC ANAESTHETISTS |
Issue Date: | 1996 |
ISSN: | 0310-057X 1448-0271 |
Statement of Responsibility: | G.L. Ludbrook, R.N. Upton, C. Grant, C. Gray |
Abstract: | The effects of bolus administration of propofol (50 mg, 100 mg and 200 mg) on cerebral blood flow and cerebral metabolic rate for oxygen were examined in a chronically catheterized sheep preparation. Depth of anaesthesia was simultaneously measured using a withdrawal response to a noxious electrical stimulus and it was demonstrated that the 100 mg dose induced moderate sedation while the 200 mg dose induced relatively deep anaesthesia. Propofol caused transient dose-dependent decreases in cerebral blood flow, despite minimal changes in blood pressure. These were accompanied by parallel decreases in cerebral metabolic rate but no change in cerebral oxygen extraction. As cerebrovascular responses in the sheep appear similar to those in man, the parallel changes in cerebral blood flow and metabolic rate demonstrated in this study supports the suitability of propofol as a neuroanaesthetic agent. |
Keywords: | Brain Animals Sheep Oxygen Propofol Anesthetics, Intravenous Anesthesia, Intravenous Random Allocation Blood Pressure Cerebrovascular Circulation Dose-Response Relationship, Drug Female |
Description: | Publisher's copy made available with the permission of the publisher © 1996 Australian Society of Anaesthetists |
DOI: | 10.1177/0310057x9602400105 |
Published version: | http://www.aaic.net.au/Article.asp?D=1995219 |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 5 |
Files in This Item:
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hdl_5902.pdf | 802.83 kB | Publisher's PDF | View/Open |
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