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Type: Journal article
Title: Long-term (5-year) antibody persistence following two- and three-dose regimens of a combined hepatitis A and B vaccine in children aged 1-11 years
Author: Marshall, H.
Nolan, T.
Diez-Domingo, J.
Rombo, L.
Sokal, E.
Mares, J.
Casanovas, J.
Kuriyakose, S.
Leyssen, M.
Jacquet, J.
Citation: Vaccine, 2010; 28(27):4411-4415
Publisher: Elsevier Sci Ltd
Issue Date: 2010
ISSN: 0264-410X
Statement of
Helen Marshall, Terry Nolan, Javier Díez Domingo, Lars Rombo, Etienne M. Sokal, Josep Marès, Josep M. Casanovas, Sherine Kuriyakose, Maarten Leyssen and Jeanne-Marie Jacquet
Abstract: This study compared the long-term persistence of anti-hepatitis A (anti-HAV) and B (anti-HBs) antibodies, 5 years after vaccination of subjects aged 1-11 years with a combined hepatitis A and B vaccine either in a two-dose (0, 6 months, Adult formulation) or a three-dose (0, 1, 6 months, Paediatric formulation) schedule. At the end of the 5 years, all subjects (100%) in both groups continued to have anti-HAV antibodies > or =15mIU/mL, while 94-97% of subjects in both groups had anti-HBs antibody concentrations > or =10mIU/mL. Subjects with anti-HBs antibody concentration < or =10mIU/mL were administered a challenge dose of hepatitis B vaccine. All subjects mounted a vigorous immune response to the challenge indicating the presence of immunological memory to HBV.
Keywords: hepatitis
Rights: © 2010 Published by Elsevier Ltd.
DOI: 10.1016/j.vaccine.2010.04.040
Appears in Collections:Aurora harvest
Paediatrics publications

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