Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/5959
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Type: Journal article
Title: The utility of open lung biopsy in patients requiring mechanical ventilation
Author: Flabouris, A.
Myburgh, J.
Citation: Chest, 1999; 115(3):811-817
Publisher: AMER COLL CHEST PHYSICIANS
Issue Date: 1999
ISSN: 0012-3692
1931-3543
Abstract: STUDY OBJECTIVE:To determine the diagnostic yield, morbidity, mortality, and therapeutic impact of the open lung biopsy in patients requiring mechanical ventilation. DESIGN:Retrospective review of patient records. SETTING:Tertiary ICU. PATIENTS:Patients with respiratory failure and diffuse pulmonary infiltrates requiring mechanical ventilation, leading up to or following an open lung biopsy. MEASUREMENTS:Information included patient demographics, organ failure, microbiological results before open-lung biopsy, Pao,/fraction of inspired oxygen values before and after biopsy, immunosuppression, timing of open lung biopsy, biopsy-related morbidity and mortality, duration of after-biopsy ventilation, open lung biopsy results, biopsy-initiated treatment alterations, and hospital outcome. RESULTS:Twenty-four patients were identified. The mean age was 48.9 years (confidence interval, 42.1 to 55.7). Twenty-one percent had respiratory infections diagnosed before open lung biopsy but not confirmed by open lung biopsy. Intraoperative complications occurred in 21% of patients, and postoperative complications occurred in 17% of patients. Operative mortality was 8.4%. The specific and the nonspecific diagnostic rates were both 46%. Lung histology was normal in two patients; one of those patients had a false-negative finding. No patient with respiratory failure plus 2 2 other organ failures survived. Alteration of therapy did not differentiate between survivors. Open lung biopsy-guided alteration of therapy directly benefited 39%, and withdrawal was possible in 8.4% of the patients. CONCLUSIONS:The multiple organ dysfunction score should be considered when deciding the relative risk of performing an open lung biopsy, which in this group of patients provided a specific diagnosis in 46% and carried a mortality rate of 8.4%.
Keywords: Lung; Humans; Lung Diseases; Respiratory Insufficiency; Critical Illness; Multiple Organ Failure; Biopsy; Respiration, Artificial; Cause of Death; Retrospective Studies; Adult; Aged; Middle Aged; Female; Male
RMID: 0030006093
DOI: 10.1378/chest.115.3.811
Appears in Collections:Anaesthesia and Intensive Care publications

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