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Type: Thesis
Title: In vitro studies on HIV-1 infection of Astrocytes.
Author: Clarke, Jennifer
Issue Date: 2007
School/Discipline: School of Molecular and Biomedical Science, Discipline of Microbiology
Abstract: HIV-1 infection of astrocytes is involved in HIV-1 induced neurological diseases and is a possible source of viral persistence. In situ studies of post mortem brain tissue indicate that HIV-1 infection of astrocytes does occur, but is restricted. Previous in vitro studies have revealed intrinsic intracellular blocks to HIV-1 transcription and translation in astrocytes. The early viral replication steps of entry, reverse transcription and integration have not been previously characterised in detail in astrocytes, and are the focus of this study.
Dissertation Note: Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2007
Keywords: HIV infections; astrocytes; AIDS dementia complex pathogenesis; central nervous system infections
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