Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/59748
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Type: Journal article
Title: Epidemiology and outcomes of peritonitis in children on peritoneal dialysis in Australasia
Author: Bordador, E.
Johnson, D.
Henning, P.
Kennedy, S.
McDonald, S.
Burke, J.
McTaggart, S.
Citation: Pediatric Nephrology, 2010; 25(9):1739-1745
Publisher: Springer-Verlag
Issue Date: 2010
ISSN: 0931-041X
1432-198X
Statement of
Responsibility: 
Esmeralda B. Bordador, David W. Johnson, Paul Henning, Sean E. Kennedy, Stephen P. McDonald, John R. Burke, Steven J. McTaggart and on behalf of the Australian and New Zealand Dialysis and Transplant Registry
Abstract: Peritonitis is a common complication and major cause of morbidity in children on peritoneal dialysis. In this retrospective longitudinal study, we analysed data retrieved from the Australian and New Zealand Dialysis and Transplant Registry (ANZDATA) on 167 patients aged less than 18 years of age who were treated with peritoneal dialysis during the period from October 2003 to December 2007. During this period there were 100 episodes of peritonitis in 57 patients (0.71 episodes/patient-year), with Gram-positive organisms most commonly isolated (44%). Peritonitis occurred frequently in the first 6 months after starting dialysis, with survival analysis showing peritonitis-free survival rates of 72%, 56% and 36% at 6 months, 1 year and 2 years respectively. Age was a weak predictor of peritonitis on univariate analysis, but previous peritonitis was the only significant predictor in a multivariate Cox proportional hazards model (adjusted hazard ratio 2.02; 95% CI: 1.20 to 3.40, p  = 0.008). Peritonitis episodes infrequently resulted in relapse (5%), recurrence (7%) or the need for either temporary or permanent haemodialysis (5% and 7% respectively) and there were no patient deaths directly attributable to peritonitis. Compared with single organism peritonitis, polymicrobial peritonitis was not associated with any statistically significant differences in outcome. Further prospective studies are required to determine the most appropriate prophylactic measures and antibiotic regimens for use in pediatric patients.
Keywords: Pediatrics; Peritoneal dialysis; Peritonitis; ANZDATA
Rights: © IPNA 2010
RMID: 0020096655
DOI: 10.1007/s00467-010-1510-5
Appears in Collections:Medicine publications

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