Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTownsend, G.-
dc.contributor.authorHughes, T.-
dc.contributor.authorBockmann, M.-
dc.contributor.authorSmith, R.-
dc.contributor.authorBrook, A.-
dc.contributor.editorKoppe, T.-
dc.identifier.citationComparative dental morphology / T. Koppe, G. Meyer and K. W. Alt (eds.); pp. 136-141-
dc.description.abstractTwo metaphors are presented to highlight concepts that could lead to a paradigm shift in dental studies of twins. The first, derived from the Song of Solomon in the Bible, refers to teeth as being twins. This viewpoint emphasises that each tooth should be viewed as a paired structure, not only with its antimere (within the same arch) but also with its isomer (in the opposing arch). The other metaphor provided by Waddington in 1957 is visual and involves 'an epigenetic landscape' that represents the processes of decision-making by cells during development. It likens the different stages of cellular decision-making to a ball rolling down an undulating landscape of interconnecting hills and valleys. This viewpoint helps to explain how distinct differences in dental phenotypes may arise both within and between monozygotic (MZ) co-twins due to relatively minor temporospatial effects during development. Measurements of maximum mesiodistal diameters of teeth in a pair of MZ twins, using calipers and also 2D and 3D imaging systems, have demonstrated that differences in dental crown size occur between antimeric pairs and between corresponding teeth of MZ co-twins. By defining new dental phenotypes that provide more comprehensive descriptions of tooth size and shape, and by drawing on the metaphors described, we are confident of providing new insights into the reasons for observed similarities and differences within, and between, the dentitions of twins. Our approaches will focus on multivariate analyses that take into account the paired arrangement of teeth and also explore epigenetic, as well as genetic and environmental, sources of variation.-
dc.description.statementofresponsibilityGrant Townsend, Toby Hughes, Michelle Bockmann, Richard Smith and Alan Brook-
dc.relation.ispartofseriesFrontiers of Oral Biology, 2009; 13-
dc.subjectMultivariate Analysis-
dc.subjectDental Research-
dc.subjectEpigenesis, Genetic-
dc.subjectTwins, Dizygotic-
dc.subjectTwins, Monozygotic-
dc.subjectModels, Biological-
dc.subjectFunctional Laterality-
dc.subjectTwin Studies as Topic-
dc.titleHow studies of twins can inform our understanding of dental morphology.-
dc.typeConference paper-
dc.contributor.conferenceInternational Symposium on Dental Morphology (14th : 2008 : Greifswald, Germany)-
dc.publisher.placePostfach Basel Switzerland CH-4009-
dc.identifier.orcidHughes, T. [0000-0001-8668-7744]-
dc.identifier.orcidBockmann, M. [0000-0001-8050-0993]-
dc.identifier.orcidBrook, A. [0000-0002-3484-3888]-
Appears in Collections:Aurora harvest 5
Dentistry publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.