Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/59802
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Type: Journal article
Title: Short-term hypertension is associated with the development of atrial fibrillation substrate: A study in an ovine hypertensive model
Author: Lau, D.
Mackenzie, L.
Kelly, D.
Psaltis, P.
Worthington, M.
Rajendram, A.
Kelly, D.
Nelson, A.
Zhang, Y.
Kuklik, P.
Brooks, A.
Worthley, S.
Faull, R.
Rao, M.
Edwards, J.
Saint, D.
Sanders, P.
Citation: Heart Rhythm, 2010; 7(3):396-404
Publisher: Elsevier Inc.
Issue Date: 2010
ISSN: 1547-5271
1556-3871
Statement of
Responsibility: 
Dennis H. Lau, Lorraine Mackenzie, Darren J. Kelly, Peter J. Psaltis, Michael Worthington, Arumuga Rajendram, Douglas R. Kelly, Adam J. Nelson, Yuan Zhang, Pawel Kuklik, Anthony G. Brooks, Stephen G. Worthley, Randall J. Faull, Mohan Rao, James Edwards, David A. Saint, Prashanthan Sanders
Abstract: Background: Hypertension is frequently complicated by the development of atrial fibrillation (AF). However, the mechanisms of this link remain poorly understood. In addition, whether short-term hypertension can result in a substrate for AF is not known. Objective: The purpose of this study was to characterize the atrial substrate predisposing to AF due to short-duration hypertension. Methods: Sixteen sheep were studied: 10 had induced hypertension for 7 ± 4 weeks via the “one-kidney, one-clip” model, and six were controls. Cardiac magnetic resonance imaging was used to assess functional changes. Open-chest electrophysiological study was performed using a custom-made 128-electrode epicardial plaque applied to both right (RA) and left atria (LA), including the Bachmann's bundle, to determine effective refractory periods (ERPs) and conduction velocity at four pacing cycle lengths from six sites. Tissue specimens were harvested for structural analysis. Results: The hypertensive group demonstrated the following compared with controls: higher blood pressure (P <.0001), enlarged LA (P <.05), reduced LA ejection fraction (P <.05), uniformly higher mean ERP (P <.001), slower mean conduction velocity (P <.001), higher conduction heterogeneity index (P <.0001), greater AF inducibility (P = .03), and increased AF durations (P = .04). Picrosirius red staining of atrial tissues revealed increased interstitial fibrosis (P <.0001). There was also evidence of increased inflammatory cell infiltrates (P <.0001). Conclusion: Short-duration hypertension is associated with significant atrial remodeling characterized by atrial enlargement/dysfunction, interstitial fibrosis, inflammation, slowed/heterogeneous conduction, increased ERP, and greater propensity for AF.
Keywords: Hypertension; Arrhythmia; Atria; Remodeling; Magnetic resonance imaging
Rights: © 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
RMID: 0020095374
DOI: 10.1016/j.hrthm.2009.11.031
Appears in Collections:Molecular and Biomedical Science publications

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