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|Title:||Interactions of N-ethylmaleimide and aluminium fluoride with GABAB receptor function in rat neocortical slices|
|Citation:||European Journal of Pharmacology, 1995; 287(2):197-200|
|Abstract:||Interactions of N-ethylmaleimide and aluminium fluoride (AlF - 4) with GABAB receptors have been examined using spontaneously discharging rat neocortical slices. The suppression of discharges by the GABAB receptor agonist baclofen (5-10 mu M) was irreversibly prevented by N-ethylmaleimide (10-50 mu M) and its analog N-phenylmaleimide (10-50 mu M), whilst superfusion of slices with NaF (10 mM) and AlCl3 (100 mu M) to form a fluoroaluminate (AlF - 4) complex markedly potentiated the action of baclofen. The lipoxygenase inhibitors, nordihydroguaiaretic acid (10-50 mu M) and eicosatetraynoic acid (10-50 mu M) or the phospholipase A2 inhibitor bromophenacylbromide (50-100 mu M) did not affect the response to baclofen. The depressant action of baclofen is evidently mediated through G-proteins, but is not dependent on arachidonic acid metabolites.|
|Keywords:||Cerebral Cortex; Animals; Rats; Rats, Sprague-Dawley; Aluminum Compounds; Baclofen; Ethylmaleimide; Receptors, GABA-B; Membrane Potentials; Drug Interactions; Male|
|Appears in Collections:||Anaesthesia and Intensive Care publications|
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