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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/5987
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dc.contributor.authorKerr, D.-
dc.contributor.authorOng, J.-
dc.contributor.authorHughes, R.-
dc.contributor.authorPrager, R.-
dc.date.issued1995-
dc.identifier.citationEuropean Journal of Pharmacology, 1995; 294(1):349-352-
dc.identifier.issn0014-2999-
dc.identifier.issn1879-0712-
dc.identifier.urihttp://hdl.handle.net/2440/5987-
dc.description.abstractRacemic 3-amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide (AHPNS), a sulphonamide analog of GABA, reversibly and competitively antagonised the concentration-dependent depression of cholinergic twitch contractions by baclofen, in the electrically stimulated guinea-pig isolated ileum, with a pA2 of 4.0 +/- 0.2. In the rat neocortex, maintained in Mg(2+)-free medium, AHPNS (100-500 microM) also reversibly antagonised the baclofen (10 microM)-induced suppression of spontaneous discharges. AHPNS is a new class of GABAB receptor antagonist that has central and peripheral blocking actions.-
dc.language.isoen-
dc.publisherNorth Holland-
dc.source.urihttp://dx.doi.org/10.1016/0014-2999(95)00688-5-
dc.subjectMuscle, Smooth-
dc.subjectIleum-
dc.subjectCentral Nervous System-
dc.subjectCerebral Cortex-
dc.subjectPeripheral Nervous System-
dc.subjectParasympathetic Nervous System-
dc.subjectAnimals-
dc.subjectGuinea Pigs-
dc.subjectRats-
dc.subjectRats, Sprague-Dawley-
dc.subjectMagnesium-
dc.subjectSulfonamides-
dc.subjectBaclofen-
dc.subjectGABA Agonists-
dc.subjectElectric Stimulation-
dc.subjectMuscle Contraction-
dc.subjectMale-
dc.subjectGABA-B Receptor Agonists-
dc.subjectGABA-B Receptor Antagonists-
dc.subjectIn Vitro Techniques-
dc.title3-Amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide, a new class of GABAB receptor antagonist in central and peripheral preparations-
dc.typeJournal article-
dc.identifier.doi10.1016/0014-2999(95)00688-5-
pubs.publication-statusPublished-
dc.identifier.orcidOng, J. [0000-0002-0958-460X]-
Appears in Collections:Anaesthesia and Intensive Care publications
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