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https://hdl.handle.net/2440/59881
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Type: | Journal article |
Title: | A substance P mediated pathway contributes to 6-hydroxydopamine induced cell death |
Author: | Thornton, E. Tran, T. Vink, R. |
Citation: | Neuroscience Letters, 2010; 481(1):64-67 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2010 |
ISSN: | 0304-3940 1872-7972 |
Statement of Responsibility: | Emma Thornton, Tuyet T. B. Tran and Robert Vink |
Abstract: | The neurotoxin 6-hydroxydopamine (6-OHDA) is used to induce dopaminergic cell death, resulting in insufficient striatal dopamine content in the basal ganglia and motor dysfunction typical of Parkinson's disease. Dopamine induces release of the neuropeptide substance P (SP) within the substantia nigra, whereas SP is able to potentiate striatal dopamine release, thus creating a positive feedback mechanism. Previous studies, however, have shown that elevated SP is detrimental to neuronal survival and motor function in acute brain injury. In the current study, we demonstrate that 6-OHDA increases SP production in meso-striatal organotypic co-culture. Moreover, there was a significant correlation between SP content and lactate dehydrogenase release, a marker of cell death, suggesting elevated SP production may contribute to 6-OHDA induced cell death in vitro. |
Keywords: | Parkinson's disease Substance P cell death organotypic co-culture dopaminergic neurones |
Rights: | Crown Copyright © 2010 Published by Elsevier Ireland Ltd. |
DOI: | 10.1016/j.neulet.2010.06.057 |
Published version: | http://dx.doi.org/10.1016/j.neulet.2010.06.057 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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