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Type: Journal article
Title: A substance P mediated pathway contributes to 6-hydroxydopamine induced cell death
Author: Thornton, E.
Tran, T.
Vink, R.
Citation: Neuroscience Letters, 2010; 481(1):64-67
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2010
ISSN: 0304-3940
Statement of
Emma Thornton, Tuyet T. B. Tran and Robert Vink
Abstract: The neurotoxin 6-hydroxydopamine (6-OHDA) is used to induce dopaminergic cell death, resulting in insufficient striatal dopamine content in the basal ganglia and motor dysfunction typical of Parkinson's disease. Dopamine induces release of the neuropeptide substance P (SP) within the substantia nigra, whereas SP is able to potentiate striatal dopamine release, thus creating a positive feedback mechanism. Previous studies, however, have shown that elevated SP is detrimental to neuronal survival and motor function in acute brain injury. In the current study, we demonstrate that 6-OHDA increases SP production in meso-striatal organotypic co-culture. Moreover, there was a significant correlation between SP content and lactate dehydrogenase release, a marker of cell death, suggesting elevated SP production may contribute to 6-OHDA induced cell death in vitro.
Keywords: Parkinson's disease
Substance P
cell death
organotypic co-culture
dopaminergic neurones
Rights: Crown Copyright © 2010 Published by Elsevier Ireland Ltd.
DOI: 10.1016/j.neulet.2010.06.057
Appears in Collections:Aurora harvest 5
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