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Type: Journal article
Title: Actions of thienyl analogs of baclofen at GABAB receptors in rat neocortical slices
Other Titles: Actions of thienyl analogs of baclofen at GABA(B) receptors in rat neocortical slices
Author: Ong, J.
Kerr, D.
Vaccher, C.
Berthelot, P.
Citation: European Journal of Pharmacology, 1997; 329(2-3):133-136
Publisher: Elsevier BV
Issue Date: 1997
ISSN: 0014-2999
Statement of
Jennifer Ong, David I.B. Kerr, Claude Vaccher, Pascal Berthelot
Abstract: In rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h), 4-amino-3-(5-methylthien-2-yl)-butanoic acid (5d), 4-amino-3-(5-bromothien-2-yl)-butanoic acid (5f) and 4-amino-3-(thien-3-yl)-butanoic acid (5j) dose-dependently suppressed the spontaneous discharges, antagonised by the GABA(B) receptor antagonist 2-hydroxysaclofen (200 microM). Their relative potencies were baclofen > 5h > 5d > 5f > 5j. These heterocyclic analogs may prove useful as GABA(B) receptor agonists in functional studies.
Keywords: Baclofen: GABAB receptor agonist; Thienyl baclofen analog; 2-Hydroxysaclofen; Neocortical slice, rat
Description: Short communication
Rights: © 1997 Elsevier Science B.V.
RMID: 0030006077
DOI: 10.1016/S0014-2999(97)00185-4
Appears in Collections:Anaesthesia and Intensive Care publications

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