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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/5994
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dc.contributor.authorKerr, D.-
dc.contributor.authorOng, J.-
dc.contributor.authorVaccher, C.-
dc.contributor.authorBerthelot, P.-
dc.contributor.authorFloquet, N.-
dc.contributor.authorVaccher, M.P.-
dc.contributor.authorDebaert, M.-
dc.date.issued1996-
dc.identifier.citationEuropean Journal of Pharmacology, 1996; 308(3):1-2-
dc.identifier.issn0014-2999-
dc.identifier.issn1879-0712-
dc.identifier.urihttp://hdl.handle.net/2440/5994-
dc.description.abstractThe GABAB receptor antagonist saclofen (3-amino-2-(4-chlorophenyl)propylsulphonic acid) has been resolved by chiral high-performance liquid chromatography. The enantiomer (R)-saclofen, but not (S)-saclofen, reversibly antagonised the (R,S)-baclofen-induced depression of cholinergic twitch contractions in the guinea-pig ileum with an apparent pA2 of 5.3. Also, 2-hydroxy-saclofen was resolved by the same method, its (S)-enantiomer yielding an apparent pA2 of 5.0. This method provides a convenient resolution of these antagonists.-
dc.description.statementofresponsibilityKerr, David I.B. ; Ong, Jennifer ; Vaccher, Claude ; Berthelot, Pascal ; Flouquet, Nathalie ; Vaccher, Marie-Pierre ; Debaert, Michel-
dc.language.isoen-
dc.publisherElsevier BV-
dc.source.urihttp://dx.doi.org/10.1016/0014-2999(96)00334-2-
dc.subjectIleum-
dc.subjectAnimals-
dc.subjectGuinea Pigs-
dc.subjectBaclofen-
dc.subjectGABA Antagonists-
dc.subjectChromatography, High Pressure Liquid-
dc.subjectStereoisomerism-
dc.subjectGABA-B Receptor Antagonists-
dc.subjectIn Vitro Techniques-
dc.titleGABAB receptor antagonism by resolved (R)-saclofen in the guinea pig ileum-
dc.typeJournal article-
dc.identifier.doi10.1016/0014-2999(96)00334-2-
pubs.publication-statusPublished-
dc.identifier.orcidOng, J. [0000-0002-0958-460X]-
Appears in Collections:Anaesthesia and Intensive Care publications
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