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Type: Journal article
Title: Effects of intravenous fructose on gastric emptying and antropyloroduodenal motility in healthy subjects
Author: Stevens, J.
Doran, S.
Russo, A.
O'Donovan, D.
Feinle-Bisset, C.
Rayner, C.
Horowitz, M.
Jones, K.
Citation: American Journal of Physiology-Gastrointestinal and Liver Physiology, 2009; 297(6):G1274-G1280
Publisher: Amer Physiological Soc
Issue Date: 2009
ISSN: 0193-1857
1522-1547
Statement of
Responsibility: 
Julie E. Stevens, Selena Doran, Antonietta Russo, Deirdre O'Donovan, Christine Feinle-Bisset, Christopher K. Rayner, Michael Horowitz and Karen L. Jones
Abstract: Gastric emptying (GE) of glucose is regulated closely, not only as a result of inhibitory feedback arising from the small intestine, but also because of the resulting hyperglycemia. Fructose is used widely in the diabetic diet and is known to empty from the stomach slightly faster than glucose but substantially slower than water. The aims of this study were to determine whether intravenous (iv) fructose affects GE and antropyloroduodenal motility and how any effects compare to those induced by iv glucose. Six healthy males (age: 26.7 ± 3.8 yr) underwent concurrent measurements of GE of a solid meal (100 g ground beef labeled with 20 MBq 99mTc-sulfur colloid) and antropyloroduodenal motility on three separate days in randomized order during iv infusion of either fructose (0.5 g/kg), glucose (0.5 g/kg), or isotonic saline for 20 min. GE (scintigraphy), antropyloroduodenal motility (manometry), and blood glucose (glucometer) were measured for 120 min. There was a rise in blood glucose (P < 0.001) after iv glucose (peak 16.4 ± 0.6 mmol/l) but not after fructose or saline. Intravenous glucose and fructose both slowed GE substantially (P < 0.005 for both), without any significant difference between them. Between t = 0 and 30 min, the number of antral pressure waves was less after both glucose and fructose (P < 0.002 for both) than saline, and there were more isolated pyloric pressure waves during iv glucose (P = 0.003) compared with fructose and saline (P = NS for both) infusions. In conclusion, iv fructose slows GE and modulates gastric motility in healthy subjects, and the magnitude of slowing of GE is comparable to that induced by iv glucose.
Keywords: glucose; glycemia scintigraphy; manometry
Rights: Copyright © 2009 by the American Physiological Society.
RMID: 0020092801
DOI: 10.1152/ajpgi.00214.2009
Appears in Collections:Medicine publications

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