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Type: Journal article
Title: Insulin secretion in healthy subjects and patients with Type 2 diabetes - role of the gastrointestinal tract
Author: Ma, J.
Rayner, C.
Jones, K.
Horowitz, M.
Citation: Best Practice & Research Clinical Endocrinology & Metabolism, 2009; 23(4):413-424
Publisher: Bailliere Tindall
Issue Date: 2009
ISSN: 1521-690X
Statement of
Jing Ma, Christopher K. Rayner, Karen L. Jones and Michael Horowitz
Abstract: Postprandial glycaemia is now recognised as the major determinant of average glycaemic control in type 2 diabetes, as assessed by glycated haemoglobin. Therefore, an understanding of the factors influencing both the rise in blood glucose and insulin secretion after a meal is fundamental to the development of dietary and pharmacological approaches to optimise glycaemic control. The gastrointestinal tract regulates the rate at which carbohydrate and other nutrients are absorbed and is the source of regulatory peptides that stimulate pancreatic insulin secretion in the setting of elevated blood glucose levels. This article highlights the importance of the gastrointestinal tract in insulin secretion and glucose homeostasis and discusses potential strategies directed at modification of gastrointestinal function in order to improve glycaemic control in the management of diabetes.
Keywords: gastric emptying; incretin hormones; GLP-1; GIP
Rights: Copyright © 2009 Elsevier Ltd All rights reserved.
RMID: 0020092824
DOI: 10.1016/j.beem.2009.03.009
Appears in Collections:Medicine publications

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