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dc.contributor.authorMa, J.en
dc.contributor.authorRayner, C.en
dc.contributor.authorJones, K.en
dc.contributor.authorHorowitz, M.en
dc.identifier.citationBest Practice & Research Clinical Endocrinology & Metabolism, 2009; 23(4):413-424en
dc.description.abstractPostprandial glycaemia is now recognised as the major determinant of average glycaemic control in type 2 diabetes, as assessed by glycated haemoglobin. Therefore, an understanding of the factors influencing both the rise in blood glucose and insulin secretion after a meal is fundamental to the development of dietary and pharmacological approaches to optimise glycaemic control. The gastrointestinal tract regulates the rate at which carbohydrate and other nutrients are absorbed and is the source of regulatory peptides that stimulate pancreatic insulin secretion in the setting of elevated blood glucose levels. This article highlights the importance of the gastrointestinal tract in insulin secretion and glucose homeostasis and discusses potential strategies directed at modification of gastrointestinal function in order to improve glycaemic control in the management of diabetes.en
dc.description.statementofresponsibilityJing Ma, Christopher K. Rayner, Karen L. Jones and Michael Horowitzen
dc.publisherBailliere Tindallen
dc.rightsCopyright © 2009 Elsevier Ltd All rights reserved.en
dc.subjectgastric emptying; incretin hormones; GLP-1; GIPen
dc.titleInsulin secretion in healthy subjects and patients with Type 2 diabetes - role of the gastrointestinal tracten
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
Appears in Collections:Medicine publications

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