Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/60635
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dc.contributor.authorMicheelsen, M.en
dc.contributor.authorMitarai, N.en
dc.contributor.authorSneppen, K.en
dc.contributor.authorDodd, I.en
dc.date.issued2010en
dc.identifier.citationPhysical Biology, 2010; 7(2):026010-1-026010-7en
dc.identifier.issn1478-3967en
dc.identifier.issn1478-3975en
dc.identifier.urihttp://hdl.handle.net/2440/60635-
dc.description.abstractCells can often choose among several stably heritable phenotypes. Examples are the expressions of genes in eukaryotic cells where long chromosomal regions can adopt persistent and heritable silenced or active states that may be associated with positive feedback in dynamic modification of nucleosomes. We generalize this mechanism in terms of bistability associated with valleys in an epigenetic landscape. A transfer matrix method was used to rigorously follow the system through the disruptive process of cell division. This combined treatment of noisy dynamics both between and during cell division provides an efficient way to calculate the stability of alternative states in a broad range of epigenetic systems.en
dc.description.statementofresponsibilityMille A Micheelsen, Namiko Mitarai, Kim Sneppen and Ian B Dodden
dc.language.isoenen
dc.publisherInstitute of Physics Publishing Ltd.en
dc.rights© IOP Publishing 2010en
dc.subjectNucleosomes; Cell Cycle; Epigenesis, Genetic; Models, Geneticen
dc.titleTheory for the stability and regulation of epigenetic landscapesen
dc.typeJournal articleen
dc.identifier.rmid0020098054en
dc.identifier.doi10.1088/1478-3975/7/2/026010en
dc.identifier.pubid34002-
pubs.library.collectionMolecular and Biomedical Science publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Molecular and Biomedical Science publications

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