Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/60636
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Type: Journal article
Title: The MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production
Author: Potter, A.
Kidd, S.
McEwan, A.
Paton, J.
Citation: Journal of Bacteriology, 2010; 192(15):4063-4066
Publisher: Amer Soc Microbiology
Issue Date: 2010
ISSN: 0021-9193
1098-5530
Statement of
Responsibility: 
Adam J. Potter, Stephen P. Kidd, Alastair G. McEwan and James C. Paton
Abstract: The NmlRsp transcription factor of Streptococcus pneumoniae is shown to induce adhC (alcohol dehydrogenase) expression in the presence of both formaldehyde and methylglyoxal. nmlRsp and adhC mutant strains display altered and opposite aerobic growth phenotypes. The nmlRsp strain exhibits increased resistance to high oxygen tension, attributable to decreased H2O2 production, which correlated with downregulation of carbamoyl phosphate synthase (carB). This indicates a possible role for AdhC in aldehyde metabolism and a broader role for NmlRsp in the regulation of carbon metabolism.
Keywords: Streptococcus pneumoniae
Hydrogen Peroxide
Oxygen
Formaldehyde
Pyruvaldehyde
Alcohol Dehydrogenase
Bacterial Proteins
DNA-Binding Proteins
Transcription Factors
Down-Regulation
Gene Expression Regulation, Bacterial
Oxidative Stress
Multigene Family
Rights: Copyright © 2010, American Society for Microbiology. All Rights Reserved.
DOI: 10.1128/JB.00383-10
Grant ID: http://purl.org/au-research/grants/nhmrc/565526
Appears in Collections:Aurora harvest 5
Molecular and Biomedical Science publications

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