Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/60636
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Type: Journal article
Title: The MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production
Author: Potter, A.
Kidd, S.
McEwan, A.
Paton, J.
Citation: Journal of Bacteriology, 2010; 192(15):4063-4066
Publisher: Amer Soc Microbiology
Issue Date: 2010
ISSN: 0021-9193
1098-5530
Statement of
Responsibility: 
Adam J. Potter, Stephen P. Kidd, Alastair G. McEwan and James C. Paton
Abstract: The NmlRsp transcription factor of Streptococcus pneumoniae is shown to induce adhC (alcohol dehydrogenase) expression in the presence of both formaldehyde and methylglyoxal. nmlRsp and adhC mutant strains display altered and opposite aerobic growth phenotypes. The nmlRsp strain exhibits increased resistance to high oxygen tension, attributable to decreased H2O2 production, which correlated with downregulation of carbamoyl phosphate synthase (carB). This indicates a possible role for AdhC in aldehyde metabolism and a broader role for NmlRsp in the regulation of carbon metabolism.
Keywords: Streptococcus pneumoniae; Hydrogen Peroxide; Oxygen; Formaldehyde; Pyruvaldehyde; Alcohol Dehydrogenase; Bacterial Proteins; DNA-Binding Proteins; Transcription Factors; Down-Regulation; Gene Expression Regulation, Bacterial; Oxidative Stress; Multigene Family
Rights: Copyright © 2010, American Society for Microbiology. All Rights Reserved.
RMID: 0020100353
DOI: 10.1128/JB.00383-10
Grant ID: http://purl.org/au-research/grants/nhmrc/565526
Appears in Collections:Molecular and Biomedical Science publications

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