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|Title:||Effect of treatment of gestational diabetes mellitus on obesity in the next generation|
|Citation:||Diabetes Care, 2010; 33(5):964-968|
|Publisher:||Amer Diabetes Assoc|
|Matthew W. Gillman, Helena Oakey, Peter A. Baghurst, Robert E. Volkmer, Jeffrey S. Robinson and Caroline A. Crowther|
|Abstract:||OBJECTIVE--Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS--Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mild GDM during pregnancy and their children. Trained nurses measured the height and weight of the children at preschool visits in a state-wide surveillance program in the state of South Australia. The main outcome measure was age- and sex-specific BMI Z score based on standards of the International Obesity Task Force. RESULTS--At birth, prevalence of macrosomia (birth weight [greater than or equal to] 4,000 g) was 5.3% among the 94 children whose mothers were in the intervention group, and 21.9% among the 105 children in the routine care control group. At 4- to 5-years-old, mean (SD) BMI Z score was 0.49 (1.20) in intervention children and 0.41 (1.40) among controls. The difference between treatment groups was 0.08 (95% CI -0.29 to 0.44), an estimate minimally changed by adjustment for maternal race, parity, age, and socio-economic index (0.08 [-0.29 to 0.45]). Evaluating BMI [greater than or equal to] 85th percentile rather than continuous BMI Z score gave similarly null results. CONCLUSIONS--Although treatment of GDM substantially reduced macrosomia at birth, it did not result in a change in BMI at age 4- to 5-years-old.|
|Keywords:||Humans; Diabetes, Gestational; Fetal Macrosomia; Prenatal Exposure Delayed Effects; Obesity; Insulin; Hypoglycemic Agents; Body Mass Index; Prevalence; Follow-Up Studies; Pregnancy; Child, Preschool; South Australia; Female; Male|
|Rights:||COPYRIGHT 2010 American Diabetes Association|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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