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Type: Journal article
Title: The mechanistic basis for sexual dysfunction in male transforming growth factor β1 null mutant mice
Other Titles: The mechanistic basis for sexual dysfunction in male transforming growth factor beta1 null mutant mice
Author: Ingman, W.
McGrath, L.
Breed, W.
Musgrave, I.
Robker, R.
Robertson, S.
Citation: Journal of Andrology, 2010; 31(2):95-107
Publisher: Amer Soc Andrology Inc
Issue Date: 2010
ISSN: 0196-3635
Statement of
W.V. Ingman, L.M. Mcgrath, W.G. Breed, I.F. Musgrave, R.L. Robker and S.A. Robertson
Abstract: The cytokine transforming growth factor β1 (TGFB1) is implicated in male sexual function. Previous behavioral studies show that Tgfb1 null mutant mice mount and display limited intromission behavior with receptive females but are unable to complete successful copulation. The studies presented here explore the physiologic basis for sexual dysfunction in Tgfb1 null mutant males. Scanning electron microscopy revealed that the surface of the penis in Tgfb1 null mutant males was abnormally coated in superficial keratinized epithelial cells. There was a significant reduction in protrusion of penile spines through the superficial tissue in Tgfb1 null mutant mice; in some mice, the spines were almost completely embedded. Histologic analysis revealed reduced skin thickness in the penis of Tgfb1 null mutant males. Nerve fibers, endothelial cells, smooth muscle actin, macrophages, and neuronal and inducible nitric oxide synthase were present in similar abundance and location in Tgfb1 null mutant mice compared with wild-type controls; however, an increase in collagen I deposition was detected. Behavioral studies revealed that Tgfb1 null mutant males undergo spontaneous noncontact erections, albeit at a reduced rate compared with control mice, and engage in less frequent genital grooming activity. These studies suggest that Tgfb1 null mutation may adversely influence copulatory behavior through effects on both altered structural integrity of the penile skin and impaired tissue compliance leading to erectile dysfunction.
Keywords: Penis; erectile dysfunction; sexual behavior; cytokine; skin; mouse model
Rights: Copyright © American Society of Andrology
RMID: 0020095846
DOI: 10.2164/jandrol.108.006569
Appears in Collections:Environment Institute publications
Obstetrics and Gynaecology publications

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