Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: Extracorporeal membrane oxygenation (ECMO) reconsidered
Author: Moran, J.
Chalwin, R.
Graham, P.
Citation: Critical Care and Resuscitation, 2010; 12(2):131-135
Publisher: Australasian Academy of Critical Care Medicine
Issue Date: 2010
ISSN: 1441-2772
Statement of
John L. Moran, Richard P. Chalwin and Petra L. Graham
Abstract: The role of extracorporeal membrane oxygenation (ECMO) in the treatment of the acute respiratory distress syndrome (ARDS) is controversial, notwithstanding the recent publication of the results of the CESAR (Conventional Ventilation or ECMO for Severe Adult Respiratory Failure) trial. Using Bayesian meta-analytic methods from three randomised controlled trials (RCTs) of ECMO in ARDS, we estimate the mortality odds ratio to be 0.78 (95% credible interval, 0.25-3.04), P (OR > 1) = 30%. Thus, a null effect of ECMO is not excluded and there appears only weak evidence of efficacy. We survey particular problems associated with the conduct of the "pragmatic" CESAR trial: composite endpoints, sample size estimation under uncertainty of baseline mortality rates, the generation of unbiased treatment comparisons, the impact of treatment non-compliance, and the uncertainty associated with cost-effectiveness and cost-utility analysis. We conclude that the CESAR trial is problematic in terms of both the clinical and economic outcomes, although observational series suggest plausible efficacy. We suggest that ECMO finds rationale as rescue therapy and that the current uncertainty of its role mandates a further RCT.
Keywords: Humans
Extracorporeal Membrane Oxygenation
Bayes Theorem
Cost-Benefit Analysis
Meta-Analysis as Topic
Randomized Controlled Trials as Topic
Respiratory Distress Syndrome
Rights: Copyright status unknown
DOI: 10.1016/S1441-2772(23)01516-8
Description (link):;dn=335916187456850;res=IELHEA
Published version:
Appears in Collections:Aurora harvest 5
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.