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dc.contributor.authorPage, A.en
dc.contributor.authorBlackshaw, L.en
dc.identifier.citationSensory nerves, 2009 / Canning, B., Spina, D. (ed./s), pp.227-260en
dc.description.abstractOesophageal pain is one of the most common reasons for physician consultation and/or seeking medication. It is most often caused by acid reflux from the stomach, but can also result from contractions of the oesophageal muscle. Different forms of pain are evoked by oesophageal acid, including heartburn and non-cardiac chest pain, but the basic mechanisms and pathways by which these are generated remain to be elucidated. Both vagal and spinal afferent pathways are implicated by basic research. The sensitivity of afferent fibres within these pathways may become altered after acid-induced inflammation and damage, but the severity of symptoms in humans does not necessarily correlate with the degree of inflammation. Gastro-oesophageal reflux disease (GORD) is caused by transient relaxations of the lower oesophageal sphincter, which are triggered by activation of gastric vagal mechanoreceptors. Vagal afferents are therefore an emerging therapeutic target for GORD. Pain in the absence of excess acid reflux remains a major challenge for treatment.en
dc.description.statementofresponsibilityAmanda J. Page and L. Ashley Blackshawen
dc.relation.ispartofseriesHandbook of experimental pharmacology ; v. 194en
dc.rights© 2009 Springer, Part of Springer Science+Business Mediaen
dc.subjectEsophagus; Esophagogastric Junction; Stomach; Afferent Pathways; Mechanoreceptors; Animals; Humans; Gastroesophageal Reflux; Pain; Receptors, Neurotransmitter; Gastrointestinal Agents; Reflex; Sensory Thresholds; Mechanotransduction, Cellular; Chemoreceptor Cells; Sensory Receptor Cellsen
dc.titleRoles of gastro-oesophageal afferents in the mechanisms and symptoms of reflux diseaseen
dc.typeBook chapteren
dc.publisher.placeHeidelberg, Germanyen
pubs.library.collectionMolecular and Biomedical Science publicationsen
dc.identifier.orcidPage, A. [0000-0002-7086-5865]en
Appears in Collections:Molecular and Biomedical Science publications

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