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Type: Journal article
Title: Metastatic carcinoid tumor: changing patterns of care over two decades
Author: Townsend, A.
Price, T.
Yeend, S.
Pittman, K.
Patterson, K.
Luke, C.
Citation: Journal of Clinical Gastroenterology, 2010; 44(3):195-199
Publisher: Lippincott Williams & Wilkins
Issue Date: 2010
ISSN: 0192-0790
Statement of
Amanda Townsend, Tim Price, Sue Yeend, Ken Pittman, Kevin Patterson and Colin Luke
Abstract: Background: Metastatic carcinoid tumors (MCTs), an important subgroup of neuroendocrine tumors, occur infrequently and often have an indolent course, limiting data on long-term treatment outcomes. We aimed to assess treatment trends at a single center over time and the impact on the outcome. Study: Patients diagnosed with carcinoid tumors in the North West Adelaide Health Service between January 1, 1985 and March 1, 2007 were identified from the South Australian Cancer Registry. Results: We identified 92 patients with carcinoid tumors; 49 had MCT. Although treatment options increased over time, the most significant change was to access octreotide therapy, with 24 receiving long-acting somatostatin analogs. Survival improved over time and the median overall survival for patients receiving long-acting somatostatin analogs was 112 months compared with 53 months for those who did not (P=0.021, hazard ratio: 2.46). Ten year survival was 40% and 22%, respectively. About 75% of evaluable patients had a biochemical response to initial therapy and a measurable response occurred in 3 of 24 (13%) patients. Conclusions: This single center experience has provided insight into current treatment options for MCT, and suggests the use of long-acting somatostatin analogs may impact on disease control and survival. However, the uptake of other treatment options seems limited and there is a need for agents that target tumor progression.
Keywords: carcinoid
neuroendocrine tumors
somatostatin analogs
Rights: Copyright © 2010 by Lippincott Williams & Wilkins
DOI: 10.1097/MCG.0b013e3181a9f10a
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