Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/61310
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Type: Journal article
Title: Toll-like receptor 4 in CNS pathologies
Author: Buchanan, M.
Hutchinson, M.
Watkins, L.
Yin, H.
Citation: Journal of Neurochemistry, 2010; 114(1):13-27
Publisher: Blackwell Publishing Ltd
Issue Date: 2010
ISSN: 0022-3042
1471-4159
Department: Clinical and Experimental Pharmacology
Statement of
Responsibility: 
Madison M. Buchanan, Mark Hutchinson, Linda R. Watkins and Hang Yin
Abstract: The responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage-like cells of the nervous system. An important contributor to microglial activation is toll-like receptor 4, a pathogen-associated molecular pattern receptor known to initiate an inflammatory cascade in response to various CNS stimuli. The present review traces new efforts to characterize and control toll-like receptor 4 in inflammatory etiologies of the nervous system.
Keywords: endogenous ligand; glia; MD2; neuroinflammation; Toll-like receptor; sepsis
Rights: © 2010 The Authors. Journal Compilation © 2010 International Society for Neurochemistry
RMID: 0020098079
DOI: 10.1111/j.1471-4159.2010.06736.x
Appears in Collections:Pharmacology publications

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