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Type: Journal article
Title: Genetic variation in the β, β-carotene-9′, 10′-dioxygenase gene and association with fat colour in bovine adipose tissue and milk
Other Titles: Genetic variation in the beta, beta-carotene-9', 10'-dioxygenase gene and association with fat colour in bovine adipose tissue and milk
Author: Tian, R.
Pitchford, W.
Morris, C.
Cullen, N.
Bottema, C.
Citation: Animal Genetics, 2010; 41(3):253-259
Publisher: Blackwell Publishing Ltd
Issue Date: 2010
ISSN: 0268-9146
Statement of
R. Tian, W. S. Pitchford, C. A. Morris, N. G. Cullen and C. D. K. Bottema
Abstract: beta, beta-carotene-9', 10'-dioxygenase (BCO2) plays a role in cleaving beta-carotene eccentrically, and may be involved in the control of adipose and milk colour in cattle. The bovine BCO2 gene was sequenced as a potential candidate gene for a beef fat colour QTL on chromosome (BTA) 15. A single nucleotide base change located in exon 3 causes the substitution of a stop codon (encoded by the A allele) for tryptophan(80) (encoded by the G allele) (c. 240G>A, p.Trp80stop, referred to herein as SNP W80X). Association analysis showed significant differences in subcutaneous fat colour and beta-carotene concentration amongst cattle with different BCO2 genotypes. Animals with the BCO2 AA genotype had more yellow beef fat and a higher beta-carotene concentration in adipose tissues than those with the GA or GG genotype. QTL mapping analysis with the BCO2 SNP W80X fitted as a fixed effect confirmed that this SNP is likely to represent the quantitative trait nucleotide (QTN) for the fat colour-related traits on BTA 15. Moreover, animals with the AA genotype had yellower milk colour and a higher concentration of beta-carotene in the milk.
Keywords: BCO2
fat colour
milk colour
subcutaneous fat.
Rights: © 2009 The Authors, Journal compilation © 2009 Stichting International Foundation for Animal Genetics
DOI: 10.1111/j.1365-2052.2009.01990.x
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Appears in Collections:Agriculture, Food and Wine publications
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