Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/61540
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMoran, L.-
dc.contributor.authorMisso, M.-
dc.contributor.authorWild, R.-
dc.contributor.authorNorman, R.-
dc.date.issued2010-
dc.identifier.citationHuman Reproduction Update, 2010; 16(4):347-363-
dc.identifier.issn1355-4786-
dc.identifier.issn1460-2369-
dc.identifier.urihttp://hdl.handle.net/2440/61540-
dc.description.abstractBACKGROUND: Polycystic ovary syndrome (PCOS) is a common condition in reproductive-aged women associated with impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and the metabolic syndrome. METHODS: A literature search was conducted (MEDLINE, CINAHL, EMBASE, clinical trial registries and hand-searching) identifying studies reporting prevalence or incidence of IGT, DM2 or metabolic syndrome in women with and without PCOS. Data were presented as odds ratio (OR) [95% confidence interval (CI)] with fixed- and random-effects meta-analysis by Mantel-Haenszel methods. Quality testing was based on Newcastle-Ottawa Scaling and The Cochrane Collaboration's risk of bias assessment tool. Literature searching, data abstraction and quality appraisal were performed by two investigators. RESULTS: A total of 2192 studies were reviewed and 35 were selected for final analysis. Women with PCOS had increased prevalence of IGT (OR 2.48, 95% CI 1.63, 3.77; BMI-matched studies OR 2.54, 95% CI 1.44, 4.47), DM2 (OR 4.43, 95% CI 4.06, 4.82; BMI-matched studies OR 4.00, 95% CI 1.97, 8.10) and metabolic syndrome (OR 2.88, 95% CI 2.40, 3.45; BMI-matched studies OR 2.20, 95% CI 1.36, 3.56). One study assessed IGT/DM2 incidence and reported no significant differences in DM2 incidence (OR 2.07, 95% CI 0.68, 6.30). One study assessed conversion from normal glucose tolerance to IGT/DM2 (OR 2.4, 95% CI 0.7, 8.0). No studies reported metabolic syndrome incidence. CONCLUSIONS: Women with PCOS had an elevated prevalence of IGT, DM2 and metabolic syndrome in both BMI and non-BMI-matched studies. Few studies have determined IGT/DM2 or metabolic syndrome incidence in women with and without PCOS and further research is required.-
dc.description.statementofresponsibilityL.J. Moran, M.L. Misso, R.A. Wild & R.J. Norman-
dc.language.isoen-
dc.publisherOxford Univ Press-
dc.rightsCopyright status unknown-
dc.source.urihttp://dx.doi.org/10.1093/humupd/dmq001-
dc.subjectHumans-
dc.subjectPolycystic Ovary Syndrome-
dc.subjectDiabetes Mellitus, Type 2-
dc.subjectGlucose Intolerance-
dc.subjectBody Mass Index-
dc.subjectIncidence-
dc.subjectPrevalence-
dc.subjectUnited States-
dc.subjectFemale-
dc.subjectMetabolic Syndrome-
dc.titleImpaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis-
dc.typeJournal article-
dc.identifier.doi10.1093/humupd/dmq001-
pubs.publication-statusPublished-
dc.identifier.orcidMoran, L. [0000-0001-5772-6484]-
dc.identifier.orcidNorman, R. [0000-0002-3118-3896]-
Appears in Collections:Aurora harvest 5
Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.