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Type: Journal article
Title: Innate Immunity
Author: Ooi, E.
Psaltis, A.
Witterick, I.
Wormald, P.
Citation: Otolaryngologic Clinics of North America, 2010; 43(3):473-487
Publisher: W B Saunders Co
Issue Date: 2010
ISSN: 0030-6665
Statement of
Eng H. Ooi, Alkis J. Psaltis, Ian J. Witterick and Peter-John Wormald
Abstract: Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.
Keywords: Innate immunity; Rhinosinusitis; Biofilms; Cigarette smoke; Toll-like receptors; Cystic fibrosis
Rights: Copyright © 2010 Elsevier Inc. All rights reserved.
RMID: 0020098153
DOI: 10.1016/j.otc.2010.02.020
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Appears in Collections:Surgery publications

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