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Type: Journal article
Title: Determinants of the induction of cortical plasticity by non-invasive brain stimulation in healthy subjects
Author: Ridding, M.
Ziemann, U.
Citation: The Journal of Physiology, 2010; 588(13):2291-2304
Publisher: Blackwell Publishing Ltd
Issue Date: 2010
ISSN: 0022-3751
Statement of
M. C. Ridding and U. Ziemann
Abstract: The ability to induce cortical plasticity with non-invasive brain stimulation (NBS) techniques has provided novel and exciting opportunities for examining the role of the human cortex during a variety of behaviours. Additionally, and importantly, the induction of lasting changes in cortical excitability can, under some conditions, reversibly modify behaviour and interact with normal learning. Such findings have driven a large number of recent studies examining whether by using such approaches it might be possible to induce functionally significant changes in patients with a large variety of neurological and psychiatric conditions including stroke, Parkinson’s disease and depression. However, even in neurologically normal subjects the variability in the neurophysiological and behavioural response to such brain stimulation techniques is high. This variability at present limits the therapeutic usefulness of these techniques. The cause of this variability is multifactorial and to some degree still unknown. However, a number of factors that can influence the induction of plasticity have been identified. This review will summarise what is known about the causes of variability in healthy subjects and propose additional factors that are likely to be important determinants. A greater understanding of these determinants is critical for optimising the therapeutic applications of non-invasive brain stimulation techniques.
Keywords: Brain
Cerebral Cortex
Electric Stimulation
Evoked Potentials, Motor
Sex Characteristics
Neuronal Plasticity
Transcranial Magnetic Stimulation
Rights: Copyright 2010 The Authors. Journal compilation Copyright 2010 The Physiological Society
DOI: 10.1113/jphysiol.2010.190314
Appears in Collections:Aurora harvest
Paediatrics publications

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